Your IP: 38.107.179.231 United States Near: United States

Lookup IP Information

2 3 4 5 6 7 8 Next

Below is the list of all allocated IP address in 13.6.0.0 - 13.6.255.255 network range, sorted by latency.

Trans-activation response element (TAR) Type: Gene; miRNA; 2° structure: Published; PubMed Seed alignment: PubMed Avg length: 60.00 nucleotides Avg identity: 93.00% The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin acts as a binding site for the Tat protein and this interaction stimulates the activity of the long terminal repeat promoter.[1] Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.[2] These miRNAs are thought to prevent infected cells from under-going apoptosis by down-regulating the genes ERCC1 and IER3.[3] References ^ Kulinski, T; Olejniczak M, Huthoff H, Bielecki L, Pachulska-Wieczorek K, Das AT, Berkhout B, Adamiak RW (2003). "The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair". J Biol Chem 278 (40): 38892–38901. doi:10.1074/jbc.M301939200. PMID 12882959.  ^ Ouellet DL, Plante I, Landry P, et al (April 2008). "Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element". Nucleic Acids Res. 36 (7): 2353–65. doi:10.1093/nar/gkn076. PMID 18299284. PMC 2367715. http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18299284.  ^ Klase Z, Winograd R, Davis J, et al (2009). "HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression". Retrovirology 6: 18. doi:10.1186/1742-4690-6-18. PMID 19220914. PMC 2654423. http://www.retrovirology.com/content/6//18.  External links Rfam page for Trans-activation response element (TAR) miRBase page for hiv1-mir-TAR This molecular or cell biology article is a stub. You can help Wikipedia by expanding it.v · d · e