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transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) Identifiers Symbol TFAP2A Alt. symbols TFAP2, AP2TF Entrez 7020 HUGO 11742 OMIM 107580 RefSeq NM_003220 UniProt P05549 Other data Locus Chr. 6 p22.3 transcription factor AP-2 beta (activating enhancer binding protein 2 beta) Identifiers Symbol TFAP2B Alt. symbols AP2-B Entrez 7021 HUGO 11743 OMIM 601601 RefSeq NM_003221 UniProt Q92481 Other data Locus Chr. 6 p12 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) Identifiers Symbol TFAP2C Entrez 7022 HUGO 11744 OMIM 601602 RefSeq NM_003222 UniProt Q92754 Other data Locus Chr. 20 q13.2 transcription factor AP-2 delta (activating enhancer binding protein 2 delta) Identifiers Symbol TFAP2D Alt. symbols TFAP2BL1 Entrez 83741 HUGO 15581 OMIM 610161 RefSeq NM_172238 UniProt Q7Z6R9 Other data Locus Chr. 6 p12.3 transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) Identifiers Symbol TFAP2E Alt. symbols AP2E Entrez 339488 HUGO 30774 RefSeq NM_178548 UniProt Q6VUC0 Other data Locus Chr. 1 p34.3 Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3] References ^ Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science 251 (4997): 1067–71. doi:10.1126/science.1998122. PMID 1998122.  ^ Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670–82. doi:10.1101/gad.5.4.670. PMID 2010091.  ^ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene 260 (1-2): 1–12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.  External links MeSH Transcription+Factor+AP-2 This article on a gene on chromosome 20 is a stub. You can help Wikipedia by expanding it.v · d · e v · d · eTranscription factors and intracellular receptors  (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1 (1.2) Basic helix-loop-helix (bHLH) ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1 (1.3) bHLH-ZIP AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2) (1.4) NF-1 NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4) (1.5) RF-X RFX (1, 2, 3, 4, 5, ANK) (1.6) Basic helix-span-helix (bHSH) AP-2 (α, β, γ, δ, ε)  (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP) (2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1 (2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (2, 3) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655) (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B  (3) Helix-turn-helix domains (3.1) Homeodomain ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2)  · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B)  · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2) (3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) (3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4) (3.4) Heat Shock Factors HSF (1, 2, 4) (3.5) Tryptophan clusters ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2 (3.6) TEA domain transcriptional enhancer factor (1, 2, 3, 4)  (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5) (4.2) STAT STAT (1, 2, 3, 4, 5, 6) (4.3) p53 p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1) (4.4) MADS box Mef2 (A, B, C, D) · SRF (4.6) TATA binding proteins TBP · TBPL1 (4.7) High-mobility group HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4)  · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4) (4.10) Cold-shock domain CSDA, YBX1 (4.11) Runt CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)   (0) Other transcription factors (0.2) HMGI(Y) HMGA (1, 2) · HBP1 (0.3) Pocket domain Rb · RBL1 · RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 · EREBP · B3 (0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma see also transcription factor/coregulator deficiencies B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)