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KF-26777 Systematic (IUPAC) name (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one Clinical data Pregnancy cat.  ? Legal status  ? Identifiers ATC code  ? Synonyms KF-26777 Chemical data Formula C16H18BrN5O  Mol. mass 376.250 g/mol SMILES eMolecules & PubChem  Y(what is this?)  [1] KF-26777 is a drug which acts as a potent and selective antagonist for the adenosine A3 receptor, with sub-nanomolar affinity (A3 Ki=0.2nM) and high selectivity over the other three adenosine receptor subtypes.[1] Simple xanthine derivatives such as caffeine and DPCPX have generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity.[2] This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · d · e References ^ Saki M, Tsumuki H, Nonaka H, Shimada J, Ichimura M (May 2002). "KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-ipurin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist"]. European Journal of Pharmacology 444 (3): 133–41. doi:10.1016/S0014-2999(02)01662-X. PMID 12063073. http://linkinghub.elsevier.com/retrieve/pii/S001429990201662X.  ^ Baraldi PG, Tabrizi MA, Gessi S, Borea PA (January 2008). "Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility". Chemical Reviews 108 (1): 238–63. doi:10.1021/cr0682195. PMID 18181659.  v · d · eAdenosinergics Receptor ligands Agonists 2-(1-Hexynyl)-N-methyladenosine • 2-Cl-IB-MECA • 2'-MeCCPA • 5'-N-ethylcarboxamidoadenosine • ATL-146e • BAY 60–6583 • CCPA • CGS-21680 • CP-532,903 • GR 79236 • LUF-5835 • LUF-5845 • N6-Cyclopentyladenosine • Regadenoson • SDZ WAG 994 • UK-432,097 Antagonists 8-Phenyl-1,3-dipropylxanthine • Acefylline • Aminophylline • Bamifylline • Caffeine • CGS-15943 • 8-Chlorotheophylline • CPX • CVT-6883 • Dimethazan • DPCPX • Fenethylline • Istradefylline • KF-26777 • MRE3008F20 • MRS-1220 • MRS-1334 • MRS-1706 • MRS-1754 • MRS-3777 • Paraxanthine • Pentoxifylline • Preladenant • Propentofylline • PSB-10 • PSB-11 • PSB 36 • PSB-603 • PSB-788 • PSB-1115 • Rolofylline • SCH-442,416 • SCH-58261 • Theobromine • Theophylline • VUF-5574 • ZM-241,385 Reuptake inhibitors Plasmalemmal ENT inhibitors Dilazep • Dipyridamole • Hexobendine • Pentoxifylline • Propentofylline Vesicular VNT inhibitors